Opioid-induced hyperalgesia: pain hurts?

Opioid-induced hyperalgesia: pain hurts?

In the current issue of the British Journal of Anaesthesia, Shin and colleagues report that propofol used for the maintenance of general anaesthesia may prevent remifentanilinduced hyperalgesia. In their study, a comparison of propofol and sevoflurane combined with either high dose or low dose of remifentanil for the maintenance of general anaesthesia in breast cancer surgery was conducted. The...

Opioid-induced hyperalgesia--worsening pain in opioid-dependent patients.

Patients with chronic opioid use are commonly treated in the emergency department (ED). Opioid-induced hyperalgesia occurs in patients consuming opioids chronically and is a paradoxical response of increased pain with opioid administration. It is difficult to diagnose and is often underrecognized, and therapies are unconventional. We report a case of a young service member with chronic pain and...

Opioid Induced Hyperalgesia

Opioid Induced Hyperalgesia

Opioid-induced hyperalgesia (OIH).

BACKGROUND AND OBJECTIVES Opioids are commonly used for pain control; however, they can cause hyperalgesia. The reason why this can happen is not known. The objective of this review was to describe the mechanisms, factors implicated, and drug modulation. CONTENTS The factors implicated in the development of opioid-induced hyperalgesia (OIH), such as duration of use, dose, and type of opioids ...